| Overview |
| bs-11403r-bf750-100ul |
| GNRHR2 Polyclonal Antibody, AbBy Fluor® 750 Conjugated |
| WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| Pig |
| Human |
| Specifications |
| AbBy Fluor® 750 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human GNRHR2 |
| 81-180/292 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| Cell membrane |
| GnRH IIR; Putative gonadotropin-releasing hormone II receptor; gonadotropin-releasing hormone type 2 receptor 2; GnRH-II-R; Type II GnRH receptor; GNRR2_HUMAN. |
| Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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