| Overview |
| bs-10286R-PE-Cy7 |
| COMP Polyclonal Antibody , PE-Cy7 Conjugated |
| WB |
| Human |
| Mouse, Rat, Dog, Cow, Sheep, Pig, Horse |
| Specifications |
| PE-Cy7 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human COMP |
| 221-320/757 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 1311 |
| P49747 |
| Secreted, Extracellular matrix |
| MED; EDM1; EPD1; PSACH; THBS5; Cartilage oligomeric matrix protein; COMP; Thrombospondin-5; TSP5 |
| May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). |
| Application Dilution |
| WB |
1:300-5000 |
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