| Overview |
| bs-10056r-bf555-100ul |
| KNDC1 Polyclonal Antibody, AbBy Fluor® 555 Conjugated |
| WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
| Others |
| Human, Mouse, Rat, Pig, Chicken |
| Specifications |
| AbBy Fluor® 555 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human KNDC1 |
| 1601-1749/1749 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 85442 |
| Cytoplasm, Nucleus |
| Cerebral protein 9; FLJ25027; hucep-9; KIAA1768; Kinase non-catalytic C-lobe domain-containing protein 1; KIND domain-containing protein 1; KNDC1; Protein very KIND; Ras-GEF domain-containing family member 2; RASGEF2; VKIND; VKIND_HUMAN; bB439H18.3; C10orf23. |
| KNDC1 is a 1,749 amino acid protein that contains two KIND domains and an N-terminal Ras-GEF domain. Expressed in the cerebral cortex, KNDC1 is a likely guanine nucleotide exchange factor (GEF). Existing as six alternatively spliced isoforms, the gene encoding KNDC1 maps to human chromosome 10q26.3 and mouse chromosome 7 F4. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman?s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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