| Overview |
| bs-0679R-PE |
| SYVN1 Polyclonal Antibody, PE Conjugated |
| WB, FCM |
| Human, Mouse |
| Rat, Dog, Cow |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human SYVN1 |
| 531-617/617 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 84447 |
| Q86TM6 |
| Cytoplasm, Cell membrane |
| DER3; HRD1; E3 ubiquitin-protein ligase synoviolin; Synovial apoptosis inhibitor 1; SYVN1; KIAA181 |
| Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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