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DKK1 Polyclonal Antibody, PE Conjugated

Applications

  • WB

Reactivity

  • Human
  • Dog

Predicted Reactivity

  • Mouse
  • Rat
Overview
Catalog # bs-2162R-PE
Product Name DKK1 Polyclonal Antibody, PE Conjugated
Applications WB
Reactivity Human, Dog
Predicted Reactivity Mouse, Rat
Specifications
Conjugation PE
Host Rabbit
Source KLH conjugated synthetic peptide derived from human DKK1
Immunogen Range 201-266/266
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 22943
Swiss Prot O94907
Subcellular location Secreted
Synonyms SK; DKK-1; Dickkopf-related protein 1; Dickkopf-1; hDkk-1; DKK1; UNQ492/PRO18
Background Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Application Dilution
WB 1:300-5000