Overview |
bs-11198R-HRP |
ProSAPiP1 Polyclonal Antibody, HRP Conjugated |
WB, ELISA, IHC-P, IHC-F |
Mouse, Rat |
Human, Dog, Cow, Pig, Horse, Rabbit |
Specifications |
HRP |
Rabbit |
KLH conjugated synthetic peptide derived from human ProSAPiP1 |
151-250/673 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
9762 |
O60299 |
Cytoplasm, Cell membrane |
PROSAPIP1; Leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; LZTS3; KIAA0552 |
The ProSAP family of proteins contain many protein-protein interaction domains and serve as scaffolding mediators within the post-synaptic density (PSD) of excitatory brain synapses. The PSD is an electron-dense structure underneath the post-synaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the pre-synaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). ProSAPiP1 (proline rich synapse associated protein interacting protein 1) is a 673 amino acid protein that interacts with the PDZ domain of Shank 3. ProSAPiP1 expression is brain-specific with highest expression within the cerebellum, hippocampus and cerebral cortex. |
Application Dilution |
WB |
1:300-5000 |
ELISA |
1:500-1000 |
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |