Integrin alpha 2/CD49b Polyclonal Antibody

$293T(Human) Cell Lysate at 30 ug probed with Integrin alpha 2\/CD49b Polyclonal Antibody (bs-10132R) at 1:300 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.$

293T(Human) Cell Lysate at 30 ug probed with Integrin alpha 2\/CD49b Polyclonal Antibody (bs-10132R) at 1:300 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.

Applications

WB
ELISA
ICC

Reactivity

Human

Predicted Reactivity

Mouse
Rat
Pig
Horse
Rabbit

Overview
Catalog #	bs-10132R
Product Name	Integrin alpha 2/CD49b Polyclonal Antibody
Applications	WB, ELISA, ICC
Reactivity	Human
Predicted Reactivity	Mouse, Rat, Pig, Horse, Rabbit
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human Integrin alpha 2/CD49b
Immunogen Range	801-900/1181
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	3673
Swiss Prot	P17301
Subcellular location	Cell membrane
Synonyms	ITGA2; Integrin alpha 2; CD49b antigen; BR; CD 49b; CD49 antigen like family member B; CD49b; CD49b; Collagen receptor; DX5 ; Glycoprotein Ia deficiency included; GP Ia; GP Ia deficiency, included; GPIa; HPA 5 included; HPA5 included; Platelet alloantigen Bra, included; Platelet antigen Br; Platelet glycoprotein GPIa; Platelet glycoprotein Ia; Platelet glycoprotein Ia/Iia; Platelet membrane glycoprotein Ia; Platelet receptor for collagen, deficiency of, included; Very late activation protein 2 receptor alpha 2 subunit; VLA 2 alpha chain; VLA 2; VLA 2 subunit alpha; VLA2 alpha chain; ITA2_HUMAN.
Background	Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.
Application Dilution
WB	1:300-5000
ELISA	1:500-1000
ICC	1:100-500