SM-164
| Overview | |
| Catalog # | bs-83122c-1-mg |
| Product Name | SM-164 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Cell-permeable Smac (DIABLO) mimetic that inhibits caspase blockers XIAP, cIAP1, and cIAP2 (Ki = 36, <1, and <1.9 nM), thus inducing apoptosis.1-3 SM-164 sensitizes cancer cells to DNA damaging agents.4 It also prevents binding of Hsp70 to XIAP.5 At high concentrations, it causes lytic cell death that is neither apoptosis nor necroptosis.6 |
| Description | CAS Number: 957135-43-2 Chemical Name: (3S,3′S,6S,6′S,10aS,10′aS)-N,N′-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[decahydro-6-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-pyrrolo[1,2-a]azocine-3-carboxamide Molecular weight: 1121.45 Formula: C62H84N14O6 Solubility: DMSO (50 mg/ml) Physical Properties: White to pale-yellow solid Purity: 98% by HPLC NMR (Conforms) |
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