Apilimod
| Overview | |
| Catalog # | bs-83076c-5-mg |
| Product Name | Apilimod |
| Specifications | |
| Storage Buffer | Beige solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level. Suppresses Th1 but not Th2 immune response.1 Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells. Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2 It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3 Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4 |
| Description | CAS Number: 541550-19-0 Chemical Name: N-[(E)-(3-Methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine Molecular weight: 418.5 Formula: C23H26N6O2 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 99% by HPLC NMR (Conforms) |
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