NH125
| Overview | |
| Catalog # | bs-83045c-5-mg |
| Product Name | NH125 |
| Specifications | |
| Storage Buffer | Yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | NH125 was originally discovered as an antibacterial agent active against various Gram-positive and -negative bacteria via inhibition of histidine protein kinase.1 It was also found to be a potent inhibitor of eukaryotic elongation factor 2 (eEF-2) kinase (IC50 = 60 nM) with efficacy against a broad spectrum of human cancer cell lines.2 Other studies have linked the anticancer effects of NH125 to induction of eEF2 phosphorylation.3,4 NH125 has also been shown to engage the EIF2a-ATF4-CHOP axis resulting in induction of DR5 expression.5 Treatment of glioma stem cells with NH125 resulted in a sustained decrease in tumor volume via activation of integrated stress response (ISR) and GADD45 pathways.5 |
| Description | CAS Number: 278603-08-0 Chemical Name: 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazlium iodide Molecular weight: 524.56 Formula: C27H45IN2 Solubility: DMSO (>25 mg/ml) Ethanol (>25 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms) |
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