Volasertib
| Overview | |
| Catalog # | bs-83034c-5-mg |
| Product Name | Volasertib |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Volasertib is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase 1, a critical controller of multiple essential steps of mitosis.1 It has shown efficacy in multiple solid xenograft tumors models1 and in clinical studies in patients with acute myeloid leukemia2. Volasertib has also been shown to potently inhibit BRD43 (Kd = 79 nM3, IC50’s bromodomains 1 and 2 of BRD4 = 300 and 770 nM respectively2). |
| Description | CAS Number: 755038-65-4 Chemical Name: N-[4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide Molecular weight: 618.82 Formula: C34H50N8O3 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms) |
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