Crenolanib
| Overview | |
| Catalog # | bs-83017c-5-mg |
| Product Name | Crenolanib |
| Specifications | |
| Storage Buffer | Pale yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ß = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4 |
| Description | CAS Number: 670220-88-9 Chemical Name: 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine Molecular weight: 443.55 Formula: C26H29N5O2 Solubility: DMSO (15 mg/ml) Ethanol (10 mg/ml) Physical Properties: White solid Purity: 97% by HPLC NMR (Conforms) |
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