IPA-3
| Overview | |
| Catalog # | bs-83011c-10-mg |
| Product Name | IPA-3 |
| Specifications | |
| Storage Buffer | Orange-yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | IPA-3 is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 µM)1 via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc422. IPA-3 has been shown to induce cell death in human leukemic cell lines3, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition4 and inhibits the growth of liver cancer cells5. |
| Description | CAS Number: 42521-82-4 Chemical Name: 1,1'-Dithiodi-2-naphthol Molecular weight: 350.45 Formula: C20H14O2S2 Solubility: DMSO (25 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC (methylene chloride; Rf=0.75) NMr (Conforms) |
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