GSK2334470

Overview
Catalog #	bs-83002c-5-mg
Product Name	GSK2334470
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It is more effective at inhibiting PDK1 substrates that are activated in the cytosol rather than at the plasma membrane.1 GSK2334470 delayed melanogenesis and metastasis in Braf(V600E)::Pten(-/-) mice.2 It also displays antitumor activity against multiple myeloma synergistically with mTORC1/2 inhibitor PP2423 and proteasome inhibitor MG-1324.
Description	CAS Number: 1227911-45-6 Chemical Name: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide Molecular weight: 462.6 Formula: C25H34N8O Solubility: DMSO (> 25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)