GSK2606414

Overview
Catalog #	bs-83000c-5-mg
Product Name	GSK2606414
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an important effector of the unfolded protein response (UPR).1 It prevented neurodegeneration in a mouse model of frontotemporal dementia2 and rodent models of Parkinsons disease via modulation of the UPR3. GSK2606414 has been reported to be a potent inhibitor of RIPK1 (IC50 = 18 nM).4 It has also displayed neuroprotective effects in various models of stroke.5-7
Description	CAS Number: 1337531-36-8 Chemical Name: 1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethenone Molecular weight: 451.44 Formula: C24H20F3N5O Solubility: DMSO (> 25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms)