GSK2606414
| Overview | |
| Catalog # | bs-83000c-5-mg |
| Product Name | GSK2606414 |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an important effector of the unfolded protein response (UPR).1 It prevented neurodegeneration in a mouse model of frontotemporal dementia2 and rodent models of Parkinsons disease via modulation of the UPR3. GSK2606414 has been reported to be a potent inhibitor of RIPK1 (IC50 = 18 nM).4 It has also displayed neuroprotective effects in various models of stroke.5-7 |
| Description | CAS Number: 1337531-36-8 Chemical Name: 1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethenone Molecular weight: 451.44 Formula: C24H20F3N5O Solubility: DMSO (> 25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms) |
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