VU0134992

Overview
Catalog #	bs-82967c-5-mg
Product Name	VU0134992
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
Description	CAS Number: 755002-90-5 Chemical Name: 2-(2-Bromo-4-propan-2-yl)phenoxy)-N-(2,2,6,6-tetramethlpiperidin-4-yl)acetamide Molecular weight: 411.38 Formula: C20H31BrN2O2 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white/tan solid Purity: 98% by TLC NMR (Conforms)