PF-9366

Overview
Catalog #	bs-82960c-5-mg
Product Name	PF-9366
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PF-9366 is an allosteric inhibitor (IC50 = 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1 It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 µM and 225 nM respectively.
Description	CAS Number: 72882-78-1 Chemical Name: 2-(7-Chloro-5-phenyl)-[1,2,4]triazolo[4,3-a]quinoline-1-yl)-N,N,dimethylethanamine Molecular weight: 350.85 Formula: C20H19ClN4 Solubility: DMSO (20 mg/ml) Physical Properties: Beige solid Purity: 98% by TLC NMr (Conforms)