SRT1720 HCl

Overview
Catalog #	bs-82956c-5-mg
Product Name	SRT1720 HCl
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	SIRT1 activator (EC1.5 = 0.16 µM, max activation = 781%).1 It reduced glucose levels and hyperinsulinemia in DIO, Lepob/ob mice and Zucker fa/fa rats. SRT1720 enhanced endurance running and protected against diet-induced obesity and insulin resistance via enhancement of oxidative metabolism in skeletal muscle, liver, and brown adipose tissue.2 It induced mitochondrial biogenesis in oxidant-induced renal proximal tube cell injury.3 SRT1720 repressed circadian clock gene expression and decreased H3 K9/K14 acetylation in a time-specific manner.4 It attenuated angiotensin II-induced atherosclerosis by inhibiting the vascular inflammatory response.5
Description	CAS Number: 1001645-58-4 Chemical Name: N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide hydrochloride Molecular weight: 506.02 Formula: C25H23N7OS·HCl Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)