3PO

Overview
Catalog #	bs-82946c-10-mg
Product Name	3PO
Specifications
Storage Buffer	Pale yellow oil
Storage Condition	-20°C
Target
Product Information	3PO is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. 3PO inhibits PFKFB3 (IC50 = 1.4 – 24 µM for various cancer cell lines), suppresses glucose uptake, and lowers intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.1 Inhibition of cancer cell metabolism via blocking the action of PFKFB3 has been studied in various models.2-4 Inhibition of PFKFB3 has been shown to induce autophagy as a survival mechanism in cancer cells.5 3PO has also been used to reduce pathological angiogenesis.6
Description	CAS Number: 18550-98-6 Chemical Name: (2E)-3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one Molecular weight: 210.23 Formula: C13H10N2O Solubility: DMSO (15 mg/ml) Ethanol (5 mg/ml) Physical Properties: Pale yellow solid Purity: 99% by HPLC, NMR (Conforms)