R162

Overview
Catalog #	bs-82940c-10-mg
Product Name	R162
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki = 28.6 µM). It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment lead to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 sensitizes LKB-1 deficient tumor cells to anoikis induction. R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2 GDH1 is a promising antimetastasis target and R162 us a useful tool for proof of principal studies.
Description	CAS Number: 64302-87-0 Chemical Name: 1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione Molecular weight: 264.28 Formula: C17H12O3 Solubility: DMSO (10 mg/ml) Ethanol (5 mg/ml) Physical Properties: Orange solid Purity: 98% by TLC, NMR (Conforms)