TH588
| Overview | |
| Catalog # | bs-82939c-5-mg |
| Product Name | TH588 |
| Specifications | |
| Storage Buffer | Yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | TH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3 |
| Description | CAS Number: 1609960-31-7 (free base) Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride Molecular weight: 331.63 Formula: C13H12Cl2N4·HCl Solubility: DMSO (5 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms) |
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