NLG919

Overview
Catalog #	bs-82923c-5-mg
Product Name	NLG919
Specifications
Storage Buffer	white solid
Storage Condition	-20°C
Target
Product Information	NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7nM; EC50 = 75nM).1 It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma.2 In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-γ and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.3
Description	CAS Number: 1402836-58-1 Chemical Name: 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol Molecular weight: 282.39 Formula: C18H22N2O Solubility: DMSO (10 mg/ml) Physical Properties: White solid Purity: 985 by TLC, NMR (Conforms)