BML283

Overview
Catalog #	bs-82921c-5-mg
Product Name	BML283
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	BML283 is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) - AC50 = 111nM.1 PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism.2,3 BML283 is an important tool for studying the effects of PKM2 and cancer metabolism.
Description	CAS Number: 562867-96-3 Chemical Name: 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)-4-(4-methoxyphenylsulfonyl)piperazine Molecular weight: 454.51 Formula: C19H22N2O7S2 Solubility: DMSO (10 mg/ml) Physical Properties: white solid Purity: 98% by TLC, NMR (Conforms)