Siramesine

Overview
Catalog #	bs-82822c-5-mg
Product Name	Siramesine
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Siramesine (Lu 28-179) is a 2 selective agonist (IC50’s: 1 = 17nM, 2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage.3,4,5 Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
Description	CAS Number: 147817-50-3 Chemical Name: 1’-[4-[1-(4-Fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4’-piperidine; Molecular weight: 454.59 Formula: C30H31FN2O Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)