SGC-iMLLT

Overview
Catalog #	bs-82776c-5-mg
Product Name	SGC-iMLLT
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3.1 YEATS domain containing proteins bind acetyl and crotonyl marks on histone tails. Selective against the two other human YEATS domains YEATS2/4 and 48 bromodomains. YEATS containing MLL-ENL leukemic cells display increased sensitivity to SGC-iMLLT versus control AML cells.2
Description	CAS Number: 2255338-25-9 Chemical Name: (S)-1-Methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazole-5-yl)-1H-indazole-5-carboxamide Molecular weight: 388.48 Formula: C22H24N6O Solubility: DMSO (50 mg/ml) Physical Properties: Off-white to beige solid Purity: >98% HPLC, NMR (Conforms)