LNT 1

Overview
Catalog #	bs-82774c-5-mg
Product Name	LNT 1
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4
Description	CAS Number: 824983-91-7 Chemical Name: 1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione Molecular weight: 332.33 Formula: C15H12N2O5S Solubility: DMSO (15 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC , NMR (Conforms)