A-196
Overview | |
Catalog # | bs-82760c-5-mg |
Product Name | A-196 |
Specifications | |
Storage Buffer | Off-white or beige solid |
Storage Condition | -20°C |
Target | |
Product Information | A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines. |
Description | CAS Number: 1982372-88-2 Chemical Name: Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine Molecular weight: 359.25 Formula: C18H16Cl2N4 Solubility: DMSO (5 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms) |