SR0987

Overview
Catalog #	bs-82752c-5-mg
Product Name	SR0987
Specifications
Storage Buffer	White or pale yellow solid
Storage Condition	-20°C
Target
Product Information	RORγt is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORγt agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORγt agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic.
Description	CAS Number: 303126-97-8 Chemical Name: 2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide Molecular weight: 397.70 Formula: C16H10F6NO2 Solubility: DMSO (>25 mg/ml), Ethanol (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)