MPEP HCl

Overview
Catalog #	bs-82751c-5-mg
Product Name	MPEP HCl
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	MPEP is a potent (IC50 = 36 nM for quisqualate-stimulated phosphoinositide hydrolysis) and selective (over mGlu1b, -2, -3, -4a, -6, -7b, and -8a) antagonist of the metabotropic glutamate receptor subtype 5 (mGlu5).1 It is a positive allosteric modulator of human mGlu4.2 MPEP inhibition of mGlu5 has been studied for the treatment of many CNS disorders including Parkinson’s3,4, Fragile X syndrome5, and addiction6.
Description	CAS Number: 219911-35-0 Chemical Name: 2-Methyl-6-(2-phenylethynyl)pyridine hydrochloride Molecular weight: 229.71 Formula: C14H11N·HCl Solubility: DMSO (20 mg/ml) Ethanol (20 mg/ml) Physical Properties: White or pale yellow solid Purity: 98% by HPLC, NMR (Conforms)