Pridopidine

Overview
Catalog #	bs-82748c-5-mg
Product Name	Pridopidine
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Pridopidine is being studied as a potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”).3 More recent studies have attributed pridopidine's effects to its being a more potent sigma-1 ligand than a D2 ligand.4,5 Displays neuroprotective/restorative effects6,7 and ameliorates central features of amyotrophic lateral sclerosis pathology8 in a sigma-1-mediated manner
Description	CAS Number: 346688-38-8 Chemical Name: 4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine Molecular weight: 281.41 Formula: C15H23NO2S Solubility: DMSO (>25 mg/mL) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)