ML210

Overview
Catalog #	bs-82747c-10-mg
Product Name	ML210
Specifications
Storage Buffer	Tan solid
Storage Condition	RT
Target
Product Information	ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
Description	CAS Number: 1360705-96-9 Chemical Name: (4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone Molecular weight: 475.32 Formula: C22H20Cl2N4O4 Solubility: DMSO (>30 mg/ml) Physical Properties: White solid Purity: 99% by HPLC, NMR (Conforms)