Tafamidis

Overview
Catalog #	bs-82707c-5-mg
Product Name	Tafamidis
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
Description	CAS Number: 594839-88-0 Chemical Name: 2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic Molecular weight: 308.12 Formula: C14H7Cl2NO3 Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)