Canagliflozin

Overview
Catalog #	bs-82692c-10-mg
Product Name	Canagliflozin
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), IC50 = 2.2 nM selective over SGLT1, IC50=910 nM.1 Dose dependently increases glucose excretion in healthy subjects.2 Displays beneficial effects in nonalcoholic fatty liver disease (NAFLD).3 Extends lifespan in male but not female mice.4 Inhibits cancer cell proliferation via inhibition of mitochondrial complex-1 supported respiration.5 Suppresses the growth of pancreatic cancer cells.6
Description	CAS Number: 842133-18-0 Chemical Name: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol Molecular weight: 444.52 Formula: C24H25FO5S Solubility: DMSO (40 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)