Verrucarin A

Overview
Catalog #	bs-82691c-1-mg
Product Name	Verrucarin A
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5
Description	CAS Number: 3148-09-2 Chemical Name: Molecular weight: 502.56 Formula: C27H34O9 Solubility: DMSO (25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC, NMR (conforms)