AA43279

Overview
Catalog #	bs-82687c-5-mg
Product Name	AA43279
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	Selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 µM). In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1
Description	CAS Number: 354812-16-1 Chemical Name: 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide Molecular weight: 248.30 Formula: C12H12N2O2S Solubility: DMSO (35 mg/ml) Physical Properties: Tan solid Purity: 97% by TLC NMr (Conforms)