Verteporfin

Overview
Catalog #	bs-82685c-5-mg
Product Name	Verteporfin
Specifications
Storage Buffer	Black solid
Storage Condition	-20°C
Target
Product Information	Verteporfin inhibits transcription by YAP/TAZ, IC50 = 2.5 µM, (via disruption of YAP-TEAD interaction) inhibiting autophagy and halting proliferation of cancer and cancer stem cell lines.1,2 Inhibits autophagosome formation.3 Reverses differentiation of Src-overexpressing embryonic stem cells.4 May be used to ablate unwanted neovasculature in the eye, esophageal mucosa, and elsewhere using light to create damaging free radicals.5
Description	CAS Number: 129497-78-5 Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester Molecular weight: 718.79 Formula: C41H42N4O8 Solubility: DMSO (14 mg/ml) Physical Properties: Black solid Purity: 98% by TLC NMR (Conforms)