Piericidin A

Overview
Catalog #	bs-82681c-1-mg
Product Name	Piericidin A
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	A potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxidoreductase (complex I).1 Piericidin A is a ubiquinone analog which binds to the ubiquinone binding site of the enzyme.2 It is an extremely useful tool for exploring the role of complex I in mitochondrial function in both normal and pathophysiology.3-5 Prevents upregulation of GRP78 and induces cell death in glucose-deprived, etoposide-resistant HT-29 cells (IC50=7.7 nM).6
Description	CAS Number: 2738-64-9 Chemical Name: 2-(10-hydroxy-3,7,9,11-tetramethyl-2,4,7,11-tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinol Molecular weight: 415.57 Formula: C25H37NO4 Solubility: DMSO (25 mg/ml) Ethanol (20 mg/ml) Physical Properties: Yellow solid Purity: 94% by HPLC NMR (Conforms)