Koningic acid
Overview | |
Catalog # | bs-82666c-1-mg |
Product Name | Koningic acid |
Specifications | |
Storage Buffer | Yellow solid |
Storage Condition | -20°C |
Target | |
Product Information | Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 μM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5 |
Description | CAS Number: 74310-84-2 Chemical Name: (2’S,5aS,6R,9aS)-1,5a,6,7,8,9a-Hexahydro-6-(1-methylethyl)-1-oxo-spiro[2-benzoxepin-9(3H)2’-oxirane]-4-carboxylic acid Molecular weight: 280.32 Formula: C15H20O5 Solubility: Water (1 mg/ml) Physical Properties: Off-white solid Purity: 95% by HPLC, NMR (Conforms) |