Rucaparib phosphate

Overview
Catalog #	bs-82665c-5-mg
Product Name	Rucaparib phosphate
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Rucaparib is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2 Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3 Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel3 and temozolamide.4 Ameliorates the cardiotoxicity of doxorubicin.5 Recently approved for human use by the FDA.
Description	CAS Number: 459868-92-9 Chemical Name: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one Molecular weight: 421.36 Formula: C19H18FN3O ∙ H3PO4 Solubility: DMSO (25 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC NMR (Conforms)