Z-Phe-Tyr-CHO

Overview
Catalog #	bs-82643c-1-mg
Product Name	Z-Phe-Tyr-CHO
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	A potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2
Description	CAS Number: 167498-29-5 Chemical Name: Molecular weight: 446.50 Formula: C26H26N2O5 Solubility: DMSO (30 mg/ml) Ethanol (50 mg/ml) Physical Properties: Off-white to pale yellow solid Purity: 98% by TLC, NMR (Conforms)