Nilvadipine

Overview
Catalog #	bs-82637c-50-mg
Product Name	Nilvadipine
Specifications
Storage Buffer	Pale yellow to off-white solid
Storage Condition	-20°C
Target
Product Information	A novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model.1 Clinically useful antihypertensive agent.2 Has been shown to prevent cognitive decline in some clinical trials.3 Produces a protective effect on glutamate neurotoxicity in retinal ganglion cells, an effect not shared by other L-type Ca2+ channel blockers such as nifedipine and diltiazem.4
Description	CAS Number: 75530-68-6 Chemical Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester Molecular weight: 385.38 Formula: C19H19N3O6 Solubility: DMSO (25 mg/ml) Ethanol (15 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)