Homoharringtonine

Overview
Catalog #	bs-82636c-5-mg
Product Name	Homoharringtonine
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
Description	CAS Number: 26833-87-4 Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate Molecular weight: 545.63 Formula: C29H39NO9 Solubility: DMSO (75 mg/ml) Physical Properties: Pale yellow to off-white solid Purity: 95% by HPLC NMR (Conforms)