MCC-950

Overview
Catalog #	bs-82624c-5-mg
Product Name	MCC-950
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	MCC-950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-11. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes2. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)3. Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome4. A valuable new tool for exploring the pathophysiology of NLRP3.
Description	CAS Number: 210826-40-7 Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt Molecular weight: 426.46 Formula: C20H23N2O5S  Na Solubility: DMSO (40 mg/ml) Water (30 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)