SB-525334

Overview
Catalog #	bs-82623c-5-mg
Product Name	SB-525334
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.
Description	CAS Number: 356559-20-1 Chemical Name: 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline Molecular weight: 343.42 Formula: C21H21N5 Solubility: DMSO (30 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC NMR (Conforms)