Leelamine HCl

Overview
Catalog #	bs-82616c-10-mg
Product Name	Leelamine HCl
Specifications
Storage Buffer	White lyophilized solid
Storage Condition	-20°C
Target
Product Information	A lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1 Induces apoptosis in breast cancer2, melanoma3 and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5 Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 µM.6
Description	CAS Number: 16496-99-4 Chemical Name: (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Molecular weight: 321.93 Formula: C20H31N ∙ HCl Solubility: DMSO (40 mg/ml) Water (9 mg/ml) Physical Properties: Off-white or beige solid Purity: 98% by TLC NMR (Conforms)