Vatalanib 2HCl

Overview
Catalog #	bs-82428c-10-mg
Product Name	Vatalanib 2HCl
Specifications
Storage Buffer	Off-white or beige solid
Storage Condition	-20°C
Target
Product Information	Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM)1. Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 µM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 µM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.
Description	CAS Number: 212141-51-0 Chemical Name: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride Molecular weight: 419.73 Formula: C20H15ClN4 2HCl Solubility: DMSO (20 mg/ml) Water (100 mg/ml) Physical Properties: White or off-white solid Purity: 98% by TLC, NMR (Conforms)