Vismodegib

Overview
Catalog #	bs-82427c-5-mg
Product Name	Vismodegib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2 Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, IC50s=1.4 and 3.0 μM respectively.3 Clinically useful for the treatment of basal cell carcinoma.4 Inhibits proliferation and induces apoptosis in colon cancer cell lines.
Description	CAS Number: 879085-55-9 Chemical Name: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide Molecular weight: 421.30 Formula: C19H14Cl2N2O3S Solubility: DMSO (200 mg/ml), Ethanol (10 mg/ml) Physical Properties: Off-white or beige solid Purity: 99% by TLC and HPLC NMR (Conforms)