Enzastaurin

Overview
Catalog #	bs-82405c-5-mg
Product Name	Enzastaurin
Specifications
Storage Buffer	Yellow-green solid
Storage Condition	-20°C
Target
Product Information	Potent and selective PKCβ inhibitor. IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway.2 Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability.3 Attenuates ampheta-mine-stimulated dopamine efflux.4 Inhibits blood-brain barrier leakiness in a mouse model.5
Description	CAS Number: 170364-57-5 Chemical Name: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione Molecular weight: 515.61 Formula: C32H29N5O2 Solubility: DMSO (7 mg/ml) Physical Properties: Orange solid Purity: 99% by HPLC, NMR (Conforms)