Dovitinib

Overview
Catalog #	bs-82404c-5-mg
Product Name	Dovitinib
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	Potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell culture and in whole animals. Selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
Description	CAS Number: 405169-16-6 Chemical Name: 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one Molecular weight: 392.43 Formula: C21H21FN6O Solubility: DMSO (30 mg/ml) Physical Properties: Yellow-green solid Purity: 99% by TLC, 99% by HPLC