Dabrafenib

Overview
Catalog #	bs-82325c-5-mg
Product Name	Dabrafenib
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3
Description	CAS Number: 1195765-45-7 Chemical Name: N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide Molecular weight: 519.56 Formula: C23H20F3N5O2S Solubility: DMSO (30 mg/ml) Ethanol (1 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC, NMR (Conforms)